# mRNA Therapies — science-database.com
> mRNA-based therapeutics and vaccines. From COVID-19 vaccines to cancer immunotherapy, personalized medicine, and next-generation mRNA delivery platforms.

- Discipline: Medicine / Biotechnology
- URL: https://science-database.com/technology/mrna-therapies
- API: https://science-database.com/api/v1/technology/mrna-therapies
- Last Updated: 2026-09-08T05:19:42.363Z
- Articles Indexed: 15

## Top Publications

### mRNA vaccines — a new era in vaccinology
- Authors: Norbert Pardi, Michael J. Hogan, Frederick Porter, Drew Weissman
- Journal: Nature Reviews Drug Discovery
- Date: 2018-01-12
- DOI: https://doi.org/10.1038/nrd.2017.243
- Citations: 4664
- Source: OpenAlex
- llms.txt: https://science-database.com/technology/mrna-therapies/paper/oa-W2782708334/llms.txt

### Lipid nanoparticles for mRNA delivery
- Authors: Xucheng Hou, Tal Zaks, Róbert Langer, Yizhou Dong
- Journal: Nature Reviews Materials
- Date: 2021-08-10
- DOI: https://doi.org/10.1038/s41578-021-00358-0
- Citations: 3923
- Source: OpenAlex
- llms.txt: https://science-database.com/technology/mrna-therapies/paper/oa-W3188940990/llms.txt

### mRNA vaccines for infectious diseases: principles, delivery and clinical translation
- Authors: Namit Chaudhary, Drew Weissman, Kathryn A. Whitehead
- Journal: Nature Reviews Drug Discovery
- Date: 2021-08-25
- DOI: https://doi.org/10.1038/s41573-021-00283-5
- Citations: 1552
- Source: OpenAlex
- llms.txt: https://science-database.com/technology/mrna-therapies/paper/oa-W3193427089/llms.txt

### mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability
- Authors: Linde Schoenmaker, Dominik Witzigmann, Jayesh A. Kulkarni, Rein Verbeke, Gideon Kersten, Wim Jiskoot, Daan J.A. Crommelin
- Journal: International Journal of Pharmaceutics
- Date: 2021-04-08
- DOI: https://doi.org/10.1016/j.ijpharm.2021.120586
- Citations: 1544
- Source: OpenAlex
- llms.txt: https://science-database.com/technology/mrna-therapies/paper/oa-W3148255637/llms.txt
- Abstract: A drawback of the current mRNA-lipid nanoparticle (LNP) COVID-19 vaccines is that they have to be stored at (ultra)low temperatures. Understanding the root cause of the instability of these vaccines may help to rationally improve mRNA-LNP product stability and thereby ease the temperature conditions...

### mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants
- Authors: Zijun Wang, Fabian Schmidt, Yiska Weisblum, Frauke Muecksch, Christopher O. Barnes, Shlomo Finkin, Dennis Schaefer-Babajew, Melissa Cipolla, Christian Gaebler, Jenna Ariel Lieberman, Thiago Y. Oliveira, Zhi Yang, Morgan E. Abernathy, Kathryn E. Huey‐Tubman, Arlene Hurley, Martina Turroja, Kamille A. West, Kristie Gordon, Katrina G. Millard, Víctor Ramos, Justin Da Silva, Jianliang Xu, Robert A. Colbert, Roshni Patel, Juan Dizon, Cecille Unson-O’Brien, Irina Shimeliovich, Anna Gazumyan, Marina Caskey, Pamela J. Björkman, Rafael Casellas, Théodora Hatziioannou, Paul D. Bieniasz, Michel C. Nussenzweig
- Journal: Nature
- Date: 2021-02-10
- DOI: https://doi.org/10.1038/s41586-021-03324-6
- Citations: 1517
- Source: OpenAlex
- llms.txt: https://science-database.com/technology/mrna-therapies/paper/oa-W3126729284/llms.txt

### The role of lipid components in lipid nanoparticles for vaccines and gene therapy
- Authors: Camilla Hald Albertsen, Jayesh A. Kulkarni, Dominik Witzigmann, Marianne Lind, Karsten Petersson, Jens B. Simonsen
- Journal: Advanced Drug Delivery Reviews
- Date: 2022-07-03
- DOI: https://doi.org/10.1016/j.addr.2022.114416
- Citations: 1163
- Source: OpenAlex
- llms.txt: https://science-database.com/technology/mrna-therapies/paper/oa-W4283803576/llms.txt

### mRNA vaccine for cancer immunotherapy
- Authors: Lei Miao, Yu Zhang, Leaf Huang
- Journal: Molecular Cancer
- Date: 2021-02-25
- DOI: https://doi.org/10.1186/s12943-021-01335-5
- Citations: 935
- Source: OpenAlex
- llms.txt: https://science-database.com/technology/mrna-therapies/paper/oa-W3130729977/llms.txt
- Abstract: mRNA vaccines have become a promising platform for cancer immunotherapy. During vaccination, naked or vehicle loaded mRNA vaccines efficiently express tumor antigens in antigen-presenting cells (APCs), facilitate APC activation and innate/adaptive immune stimulation. mRNA cancer vaccine precedes oth...

### The clinical progress of mRNA vaccines and immunotherapies
- Authors: Ann Barbier, Allen Yujie Jiang, Peng Zhang, Richard Wooster, Daniel G. Anderson
- Journal: Nature Biotechnology
- Date: 2022-05-09
- DOI: https://doi.org/10.1038/s41587-022-01294-2
- Citations: 824
- Source: OpenAlex
- llms.txt: https://science-database.com/technology/mrna-therapies/paper/oa-W4229452462/llms.txt

### Opportunities and Challenges in the Delivery of mRNA-Based Vaccines
- Authors: Abishek Wadhwa, Anas Aljabbari, Abhijeet Lokras, Camilla Foged, Aneesh Thakur
- Journal: Pharmaceutics
- Date: 2020-01-28
- DOI: https://doi.org/10.3390/pharmaceutics12020102
- Citations: 586
- Source: OpenAlex
- llms.txt: https://science-database.com/technology/mrna-therapies/paper/oa-W3004416358/llms.txt
- Abstract: In the past few years, there has been increasing focus on the use of messenger RNA (mRNA) as a new therapeutic modality. Current clinical efforts encompassing mRNA-based drugs are directed toward infectious disease vaccines, cancer immunotherapies, therapeutic protein replacement therapies, and trea...

### Clinical advances and ongoing trials of mRNA vaccines for cancer treatment
- Authors: Cathrine Lund Lorentzen, John B.A.G. Haanen, Özcan Met, Inge Marie Svane
- Journal: The Lancet Oncology
- Date: 2022-09-26
- DOI: https://doi.org/10.1016/s1470-2045(22)00372-2
- Citations: 523
- Source: OpenAlex
- llms.txt: https://science-database.com/technology/mrna-therapies/paper/oa-W4297102201/llms.txt

### Self-assembled mRNA vaccines
- Authors: Jeonghwan Kim, Yulia Eygeris, Mohit Gupta, Gaurav Sahay
- Journal: Advanced Drug Delivery Reviews
- Date: 2021-01-02
- DOI: https://doi.org/10.1016/j.addr.2020.12.014
- Citations: 509
- Source: OpenAlex
- llms.txt: https://science-database.com/technology/mrna-therapies/paper/oa-W3119364115/llms.txt

### Immunogenicity and safety of anti-SARS-CoV-2 mRNA vaccines in patients with chronic inflammatory conditions and immunosuppressive therapy in a monocentric cohort
- Authors: Ulf Geisen, Dennis K Berner, Florian Tran, Melike Sümbül, Lena Vullriede, Maria Ciripoi, Hayley M Reid, Annika Schaffarzyk, Ann Carolin Longardt, Jeanette Franzenburg, Paula Hoff, Jan Henrik Schirmer, Rainald Zeuner, Anette Friedrichs, Andrea Steinbach, Christine Knies, Robert Markewitz, Peter J. Morrison, Sascha Gerdes, Stefan Schreiber, Bimba F. Hoyer
- Journal: Annals of the Rheumatic Diseases
- Date: 2021-03-24
- DOI: https://doi.org/10.1136/annrheumdis-2021-220272
- Citations: 375
- Source: OpenAlex
- llms.txt: https://science-database.com/technology/mrna-therapies/paper/oa-W3139490202/llms.txt
- Abstract: INTRODUCTION: In light of the SARS-CoV-2 pandemic, protecting vulnerable groups has become a high priority. Persons at risk of severe disease, for example, those receiving immunosuppressive therapies for chronic inflammatory cdiseases (CIDs), are prioritised for vaccination. However, data concerning...

### Humoral immune response to COVID-19 mRNA vaccine in patients with multiple sclerosis treated with high-efficacy disease-modifying therapies
- Authors: Anat Achiron, Mathilda Mandel, Sapir Dreyer-Alster, Gil Harari, David Magalashvili, Polina Sonis, Mark Dolev, Shay Menascu, Shlomo Flechter, Rina Falb, Michael Gurevich
- Journal: Therapeutic Advances in Neurological Disorders
- Date: 2021-01-01
- DOI: https://doi.org/10.1177/17562864211012835
- Citations: 363
- Source: OpenAlex
- llms.txt: https://science-database.com/technology/mrna-therapies/paper/oa-W3158831599/llms.txt
- Abstract: BACKGROUND AND AIMS: The National Multiple Sclerosis Society and other expert organizations recommended that all patients with multiple sclerosis (MS) should be vaccinated against COVID-19. However, the effect of disease-modifying therapies (DMTs) on the efficacy to mount an appropriate immune respo...

### mRNA vaccine in cancer therapy: Current advance and future outlook
- Authors: Youhuai Li, Mina Wang, Xueqiang Peng, Yingying Yang, Qishuang Chen, Jiaxing Liu, Qing‐Bai She, Jichao Tan, Chuyuan Lou, Zehuan Liao, Xuexin Li
- Journal: Clinical and Translational Medicine
- Date: 2023-08-01
- DOI: https://doi.org/10.1002/ctm2.1384
- Citations: 144
- Source: OpenAlex
- llms.txt: https://science-database.com/technology/mrna-therapies/paper/oa-W4386116914/llms.txt
- Abstract: Messenger ribonucleic acid (mRNA) vaccines are a relatively new class of vaccines that have shown great promise in the immunotherapy of a wide variety of infectious diseases and cancer. In the past 2 years, SARS-CoV-2 mRNA vaccines have contributed tremendously against SARS-CoV2, which has prompted ...

### Advances in mRNA vaccine therapy for breast cancer research
- Authors: Jiaying Li, Ruiyuan Jiang, Jia Wang, Xiaojia Wang
- Journal: Discover Oncology
- Date: 2025-05-06
- DOI: https://doi.org/10.1007/s12672-025-02542-y
- Citations: 14
- Source: OpenAlex
- llms.txt: https://science-database.com/technology/mrna-therapies/paper/oa-W4410129890/llms.txt
- Abstract: Breast cancer represents the most prevalent cancer among women globally, constituting approximately 30% of newly diagnosed female malignancies and serving as the second leading cause of cancer-related mortality, accounting for 11.6% of deaths. Despite notable advancements in survival rates and quali...

---
Generated by science-database.com — The Knowledge Interface
Full data available at: https://science-database.com/api/v1/technology/mrna-therapies